ATAC-seq Insights

What is ATAC-seq?

ATAC-seq (Assay for Transposase-Accessible Chromatin using sequencing) is a technique used in molecular biology to identify regions of open chromatin in a genome. It utilizes a hyperactive Tn5 transposase to insert sequencing adapters into accessible DNA, which are then amplified and sequenced. This allows researchers to map regions of the genome that are more readily accessible to proteins, such as transcription factors, and therefore likely to be actively involved in gene regulation. ATAC-seq is commonly used to study chromatin structure, identify regulatory elements, and investigate gene expression patterns.

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What other technologies are related to ATAC-seq?

ATAC-seq Competitor Technologies

CUT&RUN

CUT&RUN is an alternative method to map protein-DNA interactions and chromatin modifications, serving a similar purpose to ATAC-seq in understanding gene regulation.

mentioned alongside ATAC-seq in 47% (205) of relevant job posts

CUT&Tag

CUT&Tag is another method to profile protein-DNA interactions and chromatin modifications, and like CUT&RUN, it can be used as an alternative to ATAC-seq for similar goals.

mentioned alongside ATAC-seq in 45% (122) of relevant job posts

scATAC-seq

scATAC-seq profiles chromatin accessibility at single-cell resolution, directly competing with ATAC-seq to achieve similar goals but at a single-cell level.

mentioned alongside ATAC-seq in 24% (76) of relevant job posts

ATAC-seq Complementary Technologies

ChIP-seq

ChIP-seq identifies protein-DNA interactions, offering complementary information to ATAC-seq's chromatin accessibility data. Combining the two gives a more complete picture of gene regulation.

mentioned alongside ATAC-seq in 45% (1.1k) of relevant job posts

RNA-seq

RNA-seq measures gene expression, which, when combined with ATAC-seq data on chromatin accessibility, helps to understand how regulatory regions influence transcription.

mentioned alongside ATAC-seq in 23% (1.2k) of relevant job posts

Hi-C

Hi-C maps the 3D structure of the genome, providing information on chromatin organization that complements ATAC-seq's data on chromatin accessibility.

mentioned alongside ATAC-seq in 43% (210) of relevant job posts