Hi-C Insights | Sumble

What is Hi-C?

Hi-C is a molecular biology technique used to study the three-dimensional organization of chromosomes in the nucleus. It works by cross-linking DNA in cells, fragmenting the DNA, ligating the fragments together, and then sequencing the resulting DNA. The frequency of ligation events provides information about the proximity of different genomic regions in the nucleus. It is commonly used to study chromatin structure, identify chromatin loops, and understand the relationship between genome organization and gene expression.

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What other technologies are related to Hi-C?

Hi-C Complementary Technologies

ChIP-seq

ChIP-seq identifies protein-DNA interactions, which can be combined with Hi-C data to understand the relationship between chromatin structure and protein binding.

mentioned alongside Hi-C in 13% (325) of relevant job posts

ATAC-seq

ATAC-seq maps accessible chromatin regions. Integrating ATAC-seq data with Hi-C data helps to correlate chromatin accessibility with 3D genome organization.

mentioned alongside Hi-C in 9% (210) of relevant job posts

RNA-seq

RNA-seq measures gene expression levels. Combining RNA-seq data with Hi-C data helps to understand the relationship between 3D genome structure and gene regulation.

mentioned alongside Hi-C in 5% (277) of relevant job posts