MLPA Insights | Sumble

What is MLPA?

MLPA (Multiplex Ligation-dependent Probe Amplification) is a variation of multiplex PCR that allows multiple target sequences to be amplified with only a single primer pair. It is used to detect abnormal copy numbers of specific DNA sequences, making it valuable for detecting deletions or duplications in genes. It's commonly used in genetic diagnostics, particularly for detecting aneuploidies, microdeletions, and microduplications, and for analyzing methylation patterns.

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What other technologies are related to MLPA?

MLPA Competitor Technologies

Sanger

Sanger sequencing, like MLPA, can be used for targeted sequencing, but is generally lower throughput.

mentioned alongside MLPA in 15% (104) of relevant job posts

Sanger sequencing

Sanger sequencing is a direct competitor, as it can be used for targeted sequencing, although at a lower throughput than NGS.

mentioned alongside MLPA in 9% (156) of relevant job posts

microarray

Microarrays can be used for copy number variation detection, a common application of MLPA, making them a competitor.

mentioned alongside MLPA in 8% (71) of relevant job posts

NGS

Next-generation sequencing (NGS) is a higher-throughput method for detecting copy number variations and sequence variants, making it a competitor to MLPA.

mentioned alongside MLPA in 2% (207) of relevant job posts

next-generation sequencing

Next-generation sequencing (NGS) is a higher-throughput method for detecting copy number variations and sequence variants, making it a competitor to MLPA.

mentioned alongside MLPA in 1% (138) of relevant job posts