HPLC-MS Insights

What is HPLC-MS?

HPLC-MS stands for High-Performance Liquid Chromatography-Mass Spectrometry. It is an analytical chemistry technique that combines the separation capabilities of High-Performance Liquid Chromatography (HPLC) with the detection capabilities of Mass Spectrometry (MS). HPLC separates compounds in a liquid mixture, and MS identifies and quantifies these separated compounds based on their mass-to-charge ratio. It's commonly used in pharmaceutical analysis, environmental monitoring, food safety, proteomics, and metabolomics to identify and quantify various compounds in complex mixtures.

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What other technologies are related to HPLC-MS?

HPLC-MS Competitor Technologies

HPLC-UV

High-performance liquid chromatography with UV detection is a competing technique for separating and quantifying compounds, but without the mass spec for structural information.

mentioned alongside HPLC-MS in 15% (73) of relevant job posts

GC-MS

Gas chromatography-mass spectrometry is a competing technique that separates and identifies volatile and thermally stable compounds. While it uses mass spec like HPLC-MS, the chromatography separation technique is different.

mentioned alongside HPLC-MS in 3% (346) of relevant job posts

NMR

Nuclear magnetic resonance spectroscopy is a competing technique used for structural elucidation and compound identification, though it relies on different principles than HPLC-MS.

mentioned alongside HPLC-MS in 1% (135) of relevant job posts

ICP-MS

Inductively coupled plasma mass spectrometry is primarily used for elemental analysis, while HPLC-MS is used for molecular analysis. Both can use mass spec, but for different analyses.

mentioned alongside HPLC-MS in 1% (112) of relevant job posts

HPLC-MS Complementary Technologies

Sciex Analyst

Software often used to control Sciex mass spectrometers, which are coupled with HPLC for data acquisition and analysis. It complements HPLC-MS workflows.

mentioned alongside HPLC-MS in 38% (56) of relevant job posts

HPLC

High-performance liquid chromatography is a core component of HPLC-MS. HPLC separates compounds before they are analyzed by the mass spectrometer.

mentioned alongside HPLC-MS in 0% (283) of relevant job posts