SPR Insights | Sumble

What is SPR?

Surface Plasmon Resonance (SPR) is a label-free and real-time optical technique used to study biomolecular interactions. It detects changes in the refractive index on a sensor surface caused by the binding or dissociation of molecules. SPR is widely applied in drug discovery, protein interaction analysis, and biosensing.

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What other technologies are related to SPR?

SPR Competitor Technologies

BLI

Bio-Layer Interferometry (BLI) is a label-free technology for measuring biomolecular interactions, similar to SPR, making it a direct competitor.

mentioned alongside SPR in 65% (687) of relevant job posts

MST

Microscale Thermophoresis (MST) is another label-free technology used to measure biomolecular interactions by detecting changes in the movement of molecules along a temperature gradient, making it a competitor to SPR.

mentioned alongside SPR in 23% (295) of relevant job posts

Octet

Octet is a brand of BLI instruments. BLI is a label-free technology for measuring biomolecular interactions, similar to SPR, making it a direct competitor.

mentioned alongside SPR in 22% (180) of relevant job posts

Biacore

Biacore is a brand name of SPR instruments. As SPR instruments, these are a direct competitor.

mentioned alongside SPR in 16% (96) of relevant job posts

SPR Complementary Technologies

ITC

Isothermal Titration Calorimetry (ITC) measures the heat changes upon binding, providing thermodynamic parameters that complement the kinetic and affinity data from SPR.

mentioned alongside SPR in 55% (488) of relevant job posts

SEC-MALS

Size-Exclusion Chromatography with Multi-Angle Light Scattering (SEC-MALS) is used to determine the absolute molecular weight and oligomeric state of molecules in solution, which can complement SPR data by providing information about complex formation and stoichiometry.

mentioned alongside SPR in 17% (121) of relevant job posts

X-ray crystallography

X-ray crystallography provides high-resolution structural information of interacting molecules, offering a detailed understanding of binding interfaces that complements the kinetic and affinity data from SPR.

mentioned alongside SPR in 13% (153) of relevant job posts