FISH Insights | Sumble

What is FISH?

FISH, or Fluorescence In Situ Hybridization, is a cytogenetic technique used to detect and localize specific DNA sequences on chromosomes. It relies on using fluorescent probes that bind to complementary DNA sequences of interest. It is commonly used in medical diagnostics for identifying chromosomal abnormalities associated with genetic diseases and cancers. It is also used in research to map genes and study genome organization.

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What other technologies are related to FISH?

FISH Competitor Technologies

karyotyping

Karyotyping is a cytogenetic technique used to visualize chromosomes and can detect large chromosomal abnormalities, making it a competitor to FISH for certain applications.

mentioned alongside FISH in 63% (69) of relevant job posts

cytogenetics

Cytogenetics, the study of chromosomes and their abnormalities, is a broader field that includes techniques like karyotyping and FISH, but these techniques can be used for similar diagnostic purposes.

mentioned alongside FISH in 36% (61) of relevant job posts

microarray

Microarrays can detect copy number variations and gene expression changes on a genome-wide scale, offering an alternative approach to FISH for certain applications.

mentioned alongside FISH in 13% (111) of relevant job posts

NGS

Next-generation sequencing (NGS) provides a high-throughput method for analyzing DNA sequences, making it a competitor to FISH for detecting genetic abnormalities.

mentioned alongside FISH in 2% (279) of relevant job posts

next-generation sequencing

Next-generation sequencing (NGS) provides a high-throughput method for analyzing DNA sequences, making it a competitor to FISH for detecting genetic abnormalities.

mentioned alongside FISH in 1% (146) of relevant job posts

FISH Complementary Technologies

PCR

PCR can amplify specific DNA sequences for FISH analysis, making it a complementary technique.

mentioned alongside FISH in 1% (283) of relevant job posts

ddPCR

ddPCR can be used to validate FISH results by accurately quantifying the copy number of specific DNA sequences. Therefore, it can be seen as complementary.

mentioned alongside FISH in 1% (60) of relevant job posts

qPCR

qPCR can be used to quantify the expression levels of genes targeted by FISH probes, providing additional information and validation. Therefore, it can be seen as complementary.

mentioned alongside FISH in 1% (123) of relevant job posts