single-cell RNA sequencing Insights

What is single-cell RNA sequencing?

Single-cell RNA sequencing (scRNA-seq) is a high-throughput technology used to measure the gene expression levels of individual cells. It provides a snapshot of the transcriptome of each cell, enabling researchers to study cellular heterogeneity, identify rare cell types, and investigate gene expression dynamics in complex tissues and biological systems. Common uses include characterizing cell populations in development, disease, and response to treatment.

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What other technologies are related to single-cell RNA sequencing?

single-cell RNA sequencing Competitor Technologies

spatial transcriptomics

Spatial transcriptomics provides gene expression information while preserving spatial context, offering an alternative approach to single-cell RNA sequencing for understanding tissue organization and cellular interactions.

mentioned alongside single-cell RNA sequencing in 10% (245) of relevant job posts

proteomics

Proteomics provides information about protein expression, offering an alternative to transcriptomics for understanding cellular function and regulation. It is a competitor because it uses a different biomolecule to infer function and cell state.

mentioned alongside single-cell RNA sequencing in 2% (80) of relevant job posts

single-cell RNA sequencing Complementary Technologies

flow cytometry

Flow cytometry is used for cell sorting to enrich specific cell populations prior to single-cell RNA sequencing. It can also be used for validation of scRNA-seq results by quantifying protein expression in identified cell types.

mentioned alongside single-cell RNA sequencing in 1% (362) of relevant job posts

confocal microscopy

Confocal microscopy can validate single-cell RNA sequencing findings by visualizing protein expression patterns in specific cell types or spatial locations. It can provide spatial confirmation of gene expression.

mentioned alongside single-cell RNA sequencing in 1% (64) of relevant job posts

immunohistochemistry

Immunohistochemistry (IHC) can be used to validate single-cell RNA sequencing results by visualizing the protein expression of identified marker genes in tissue sections. This provides spatial context to scRNA-seq data.

mentioned alongside single-cell RNA sequencing in 1% (75) of relevant job posts