shRNA (short hairpin RNA) is a type of RNA interference (RNAi) technology used to silence gene expression. It is a DNA sequence that is transcribed into a short RNA molecule with a tight hairpin turn that can be processed by the cell into siRNA. This siRNA then targets a specific mRNA molecule for degradation or translational repression, effectively reducing the production of the protein encoded by that mRNA. shRNA is commonly delivered using viral vectors, allowing for stable and long-term gene silencing in cells.
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