PBPK, or Physiologically Based Pharmacokinetic modeling, is a mathematical modeling technique used to predict the absorption, distribution, metabolism, and excretion (ADME) of a drug or chemical substance within the body. It utilizes physiological and biochemical information to create a virtual representation of the organism, allowing researchers to simulate the fate of a compound. PBPK models are commonly used in drug development, risk assessment, and chemical safety evaluation to predict tissue concentrations, assess bioavailability, and extrapolate data across species or populations.
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