What is lentiviral transduction?

Lentiviral transduction is a method for gene delivery using lentiviruses as vectors. Lentiviruses are a subclass of retroviruses that can infect both dividing and non-dividing cells, making them particularly useful for delivering genes into a wide range of cell types, including neurons and hematopoietic stem cells. The viral genome is modified to carry the desired gene, and the resulting virus is used to 'infect' target cells, integrating the gene into the host cell's genome. This leads to long-term, stable expression of the delivered gene. Lentiviral transduction is commonly used in research for gene editing, gene therapy, and creating stable cell lines.