LC-MS/MS Insights

What is LC-MS/MS?

LC-MS/MS, or Liquid Chromatography-Tandem Mass Spectrometry, is an analytical technique that combines the physical separation capabilities of liquid chromatography (LC) with the mass analysis capabilities of tandem mass spectrometry (MS/MS). It is commonly used for identifying and quantifying specific compounds within complex mixtures. The LC separates the components, and the MS/MS identifies and quantifies them based on their mass-to-charge ratio and fragmentation patterns. It's widely used in proteomics, metabolomics, drug discovery, environmental monitoring, and food safety.

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What other technologies are related to LC-MS/MS?

LC-MS/MS Competitor Technologies

GC/MS/MS

GC/MS/MS is a similar tandem mass spectrometry technique, but coupled with gas chromatography instead of liquid chromatography. Can be used for similar analyses but for volatile compounds.

mentioned alongside LC-MS/MS in 72% (923) of relevant job posts

GC-MS

GC-MS is a mass spectrometry technique coupled with gas chromatography. Can be used for similar analyses but for volatile compounds.

mentioned alongside LC-MS/MS in 12% (1.4k) of relevant job posts

LC-MS/MS Complementary Technologies

X500QTOF

The X500QTOF is a specific type of LC-MS/MS instrument (Q-TOF) used for high-resolution accurate mass measurements, often in conjunction with triple quadrupole instruments. It can provide complementary information for compound identification.

mentioned alongside LC-MS/MS in 100% (247) of relevant job posts

QTRAP 6500+

The QTRAP 6500+ is a hybrid triple quadrupole/linear ion trap mass spectrometer often coupled with LC. It provides both quantitative and qualitative analyses, thus complementing typical LC-MS/MS workflows.

mentioned alongside LC-MS/MS in 99% (246) of relevant job posts

LC/QTOF

LC/QTOF combines liquid chromatography with a quadrupole time-of-flight mass spectrometer. It's often used for high-resolution accurate mass measurements, which can complement LC-MS/MS data for compound identification.

mentioned alongside LC-MS/MS in 78% (272) of relevant job posts