GC-MSMS Insights

What is GC-MSMS?

GC-MS/MS refers to Gas Chromatography-Tandem Mass Spectrometry. It is an analytical technique that combines the separation capabilities of gas chromatography (GC) with the mass analysis capabilities of tandem mass spectrometry (MS/MS). In GC-MS/MS, the GC first separates volatile and semi-volatile compounds in a sample. The separated compounds are then ionized and fragmented in the first mass spectrometer (MS1). Selected ions from MS1 are then further fragmented in a collision cell, and the resulting fragment ions are analyzed by the second mass spectrometer (MS2). This technique is used for highly sensitive and selective identification and quantification of target compounds in complex matrices, such as in environmental monitoring, food safety, and drug analysis.

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What other technologies are related to GC-MSMS?

GC-MSMS Competitor Technologies

LC-MSMS

LC-MSMS is a competitor to GC-MSMS because it achieves similar analytical goals (identifying and quantifying compounds), but is better suited for non-volatile or thermally labile compounds that are not amenable to gas chromatography. Both are tandem mass spectrometry techniques.

mentioned alongside GC-MSMS in 19% (72) of relevant job posts

GC-MSMS Complementary Technologies

GC-MS

GC-MS is complementary because GC-MSMS builds upon the capabilities of GC-MS by adding a second stage of mass analysis (MS/MS) for improved selectivity and sensitivity. GC-MS is often used as a screening method, with GC-MSMS providing confirmation and quantification.

mentioned alongside GC-MSMS in 1% (77) of relevant job posts