What is GC-MSMS?

GC-MS/MS refers to Gas Chromatography-Tandem Mass Spectrometry. It is an analytical technique that combines the separation capabilities of gas chromatography (GC) with the mass analysis capabilities of tandem mass spectrometry (MS/MS). In GC-MS/MS, the GC first separates volatile and semi-volatile compounds in a sample. The separated compounds are then ionized and fragmented in the first mass spectrometer (MS1). Selected ions from MS1 are then further fragmented in a collision cell, and the resulting fragment ions are analyzed by the second mass spectrometer (MS2). This technique is used for highly sensitive and selective identification and quantification of target compounds in complex matrices, such as in environmental monitoring, food safety, and drug analysis.