What is Dissolution Testing?

Dissolution testing is a standardized method used in the pharmaceutical industry to determine the rate at which a drug substance dissolves from a solid dosage form, such as a tablet or capsule. It is a critical quality control test used to assess the bioavailability and consistency of drug products. The test involves placing the dosage form in a dissolution apparatus containing a specific volume of dissolution medium at a controlled temperature and agitation rate. Samples are withdrawn at specified time intervals and analyzed to quantify the amount of drug dissolved. The resulting dissolution profile provides information about the drug's release characteristics and its potential for absorption in the body. It is commonly used in drug development, quality control, and to ensure batch-to-batch consistency of manufactured drug products.