cryo-electron microscopy Insights

What is cryo-electron microscopy?

Cryo-electron microscopy (cryo-EM) is a form of transmission electron microscopy (TEM) where samples are studied at cryogenic temperatures (typically liquid nitrogen temperatures). Cryo-EM is used to determine the 3D structures of biological macromolecules, such as proteins and nucleic acids, at near-atomic resolution. Samples are rapidly cooled (vitrified) to preserve their native structure within a thin film of amorphous ice, avoiding the formation of crystalline ice that can damage or distort the sample.

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What other technologies are related to cryo-electron microscopy?

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X-ray crystallography

X-ray crystallography, like cryo-EM, is used to determine the atomic and molecular structure of a crystal. In many cases, both X-ray crystallography and cryo-EM compete as methods for structural determination, though cryo-EM is often used when crystals are difficult to obtain or are of poor quality.

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