CITE-seq Insights

What is CITE-seq?

CITE-seq (Cellular Indexing of Transcriptomes and Epitopes by Sequencing) is a method that allows simultaneous measurement of gene expression and protein abundance in single cells. It combines traditional RNA sequencing with antibody-derived tags that are conjugated to oligonucleotides. These tags bind to specific cell surface proteins, and their abundance can be quantified along with mRNA levels using next-generation sequencing. CITE-seq is commonly used to gain a more comprehensive understanding of cellular identity and function, study immune cell populations, and investigate cellular heterogeneity.

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What other technologies are related to CITE-seq?

CITE-seq Competitor Technologies

proteomics

Proteomics, especially single-cell proteomics, aims to measure protein abundance, which is also a goal of CITE-seq. While CITE-seq uses antibody-oligo conjugates for protein detection, proteomics uses mass spectrometry.

mentioned alongside CITE-seq in 1% (61) of relevant job posts

flow cytometry

Flow cytometry measures protein expression on single cells using fluorescently labeled antibodies, similar to CITE-seq's protein measurement aspect, but without the transcriptomic information.

mentioned alongside CITE-seq in 0% (94) of relevant job posts