Burrows-Wheeler Aligner (BWA) is a software package for mapping relatively short DNA sequences against a large reference genome, such as the human genome. It is commonly used in bioinformatics for tasks like variant calling, genome resequencing, and identifying structural variations in DNA sequences. BWA uses the Burrows-Wheeler Transform (BWT) to efficiently compress and index the reference genome, allowing for fast and accurate alignment of sequencing reads even with mismatches and gaps.
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