ATACseq Insights

What is ATACseq?

ATAC-seq (Assay for Transposase-Accessible Chromatin using sequencing) is a technique used in molecular biology to assess genome-wide chromatin accessibility. It utilizes a hyperactive Tn5 transposase to insert sequencing adapters into open chromatin regions, followed by next-generation sequencing to identify these regions. This allows researchers to map areas of the genome that are accessible to regulatory proteins, thereby providing insights into gene regulation, transcription factor binding, and other chromatin-related processes.

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What other technologies are related to ATACseq?

ATACseq Complementary Technologies

ChIPseq

ChIP-seq identifies protein-DNA interactions, providing information on transcription factor binding and histone modifications, which complements ATAC-seq's open chromatin profiling.

mentioned alongside ATACseq in 36% (101) of relevant job posts

RNAseq

RNA-seq measures gene expression levels, offering insight into the functional consequences of chromatin accessibility identified by ATAC-seq.

mentioned alongside ATACseq in 6% (158) of relevant job posts

single cell RNAseq

Single-cell RNA-seq provides gene expression data at single-cell resolution, which, when combined with ATAC-seq, reveals cell-type-specific regulatory mechanisms.

mentioned alongside ATACseq in 9% (52) of relevant job posts