Spravato (esketamine) is a nasal spray used to treat treatment-resistant depression (TRD) and depressive symptoms in adults with major depressive disorder (MDD) with suicidal thoughts or actions. It is administered in conjunction with an oral antidepressant. Esketamine is a Schedule III controlled substance, and Spravato is only available through a restricted distribution program due to the risk of serious adverse outcomes from sedation, dissociation, abuse, and misuse.
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