What is RFdiffusion?

RFdiffusion (Rose Diffusion) is a computational method used for protein design. It leverages diffusion models, similar to those used in image generation, to 'hallucinate' or design novel protein structures and sequences. Users can specify constraints or desired properties, and RFdiffusion generates proteins that satisfy those requirements. This technology is commonly used to design proteins with specific functions, such as binding to a target molecule or catalyzing a specific reaction, as well as scaffolds for targeted protein degradation.