PNA most commonly refers to Peptide Nucleic Acid. It is an artificially synthesized polymer similar to DNA or RNA. However, instead of a deoxyribose or ribose sugar backbone, PNA has a peptide backbone composed of repeating N-(2-aminoethyl)-glycine units. PNAs bind to DNA and RNA with high affinity and specificity, making them useful in research, diagnostics, and therapeutics. They are used in applications like antisense technology, PCR clamping, and as probes for in situ hybridization. PNA is resistant to degradation by nucleases and proteases, offering advantages over DNA and RNA in certain applications. PNA can also stand for Process Network Analyzer, used for network testing.
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