Mendelian randomization (MR) is a method that uses genetic variants as instrumental variables to infer causal relationships between modifiable exposures (e.g., biomarkers or risk factors) and health outcomes. Because genetic variants are randomly allocated at conception, MR can mimic a randomized controlled trial and reduce the potential for confounding and reverse causation that can plague observational studies. It is commonly used in epidemiology to assess the causal effects of various exposures on disease risk.
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