Tech Insights

high content imaging

Last updated May 16, 2025, generated by Sumble

What is high content imaging?

High-content imaging (HCI), also known as high-content screening (HCS) or automated microscopy, is a cell-based assay approach used in drug discovery, basic research, and toxicology. It combines automated microscopy, image analysis, and robotic handling to acquire and analyze multiple parameters from cells or other biological samples. It is commonly used to study complex biological processes at the cellular level, such as cell signaling, protein expression, and cell morphology, and for screening large libraries of compounds for their effects on these processes.

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What other technologies are related to high content imaging?

high content imaging Competitor Technologies

flow cytometry

Flow cytometry is a cell analysis technique that measures and analyzes multiple characteristics of cells in a fluid stream. While it does not generate images in the same way as high content imaging, it is used for similar applications like cell counting, cell health, and immunophenotyping.

mentioned alongside high content imaging in 1% (262) of relevant job posts

ELISA

ELISA (Enzyme-Linked Immunosorbent Assay) is a plate-based assay technique designed for detecting and quantifying soluble substances such as peptides, proteins, antibodies, and hormones. While ELISA is a lower throughput assay than high content imaging, it is used for similar applications like quantifying protein expression.

mentioned alongside high content imaging in 1% (209) of relevant job posts

MSD

MSD (Meso Scale Discovery) is a plate-based assay technique designed for detecting and quantifying soluble substances such as peptides, proteins, antibodies, and hormones. While MSD is a lower throughput assay than high content imaging, it is used for similar applications like quantifying protein expression.

mentioned alongside high content imaging in 2% (61) of relevant job posts

high content imaging Complementary Technologies

confocal microscopy

Confocal microscopy is an imaging technique that can be used to acquire high-resolution optical sections from thick samples. It's often used in conjunction with high content imaging to provide higher resolution data for certain regions of interest.

mentioned alongside high content imaging in 1% (62) of relevant job posts

CRISPR

CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a genome editing technology that can be used to modify genes in cells. High content imaging can then be used to analyze the effects of the genetic modifications at the cellular level.

mentioned alongside high content imaging in 1% (72) of relevant job posts

qPCR

qPCR (quantitative polymerase chain reaction) is a technique used to quantify the amount of a specific DNA or RNA molecule. High content imaging can be used in conjunction with qPCR to analyze gene expression changes at the cellular level.

mentioned alongside high content imaging in 1% (122) of relevant job posts