What is gnomAD?

gnomAD (the Genome Aggregation Database) is a resource developed by the Broad Institute that aggregates and harmonizes exome and genome sequencing data from a variety of large-scale sequencing projects. It is used extensively in human genetics research to assess the allele frequencies of genetic variants in diverse populations, helping researchers distinguish between common polymorphisms and rare disease-causing mutations. By providing a comprehensive catalog of human genetic variation, gnomAD aids in the interpretation of genetic findings in both clinical and research settings.