Endotoxins are toxins that are part of the outer membrane of Gram-negative bacteria. They are lipopolysaccharides (LPS) and are released when the bacteria die or undergo lysis. Endotoxins can cause a variety of harmful effects in humans and animals, including fever, inflammation, shock, and even death. Endotoxin testing is important in the pharmaceutical and medical device industries to ensure that products are free from contamination. Common methods for endotoxin detection include the Limulus amebocyte lysate (LAL) assay and recombinant factor C (rFC) assays.
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