ELSD Insights | Sumble

What is ELSD?

ELSD stands for Evaporative Light Scattering Detector. It is a universal detector used in liquid chromatography (LC) for compounds that lack a strong UV chromophore or are difficult to detect by other methods. The mobile phase is evaporated, and the resulting non-volatile analyte particles scatter light, which is then detected. It is commonly used for the analysis of sugars, lipids, and polymers.

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What other technologies are related to ELSD?

ELSD Competitor Technologies

RI

Refractive Index (RI) detectors are used for compounds without a UV chromophore, similarly to ELSD. However, RI detectors are known for their low sensitivity and are susceptible to drift.

mentioned alongside ELSD in 18% (58) of relevant job posts

CAD

Charged Aerosol Detectors (CAD) are another type of universal detector for LC. Like ELSD, they can detect compounds without a UV chromophore, offering an alternative approach for such analyses. CAD generally offers better sensitivity than ELSD.

mentioned alongside ELSD in 0% (116) of relevant job posts

ELSD Complementary Technologies

LC-MS

LC-MS combines liquid chromatography with mass spectrometry, providing both separation and structural information. It complements ELSD, which offers quantitation of non-UV absorbing compounds but lacks structural information.

mentioned alongside ELSD in 1% (98) of relevant job posts

MS

Mass Spectrometry (MS) provides structural information about compounds separated by LC. It complements ELSD, which offers quantitation of non-UV absorbing compounds but lacks structural information.

mentioned alongside ELSD in 1% (56) of relevant job posts