COBRA (COnstraints-Based Reconstruction and Analysis) is a widely used framework for studying biological systems. It provides tools and methods for building, analyzing, and simulating genome-scale metabolic models (GEMs). GEMs represent the complete set of biochemical reactions occurring within an organism or cell, and COBRA methods allow researchers to predict metabolic fluxes, identify essential genes, and analyze the impact of genetic or environmental perturbations on cellular metabolism. It's frequently used in systems biology, metabolic engineering, and synthetic biology.
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